The Lumbar Fusion Page

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General Information | How does it stop the pain? | Failure Rate | Fusion Techniques | Fusion Alternatives |
(*It would be behoove the reader to study the Disc Anatomy Page before reading through this page, for I am going to make the assumption that you understand the basics of lumbar spine and disc anatomy.)
Warning: Fusion of the lumbar spine is an end-of-the-road treatment intervention that is typically for the treatment of chronic back pain greater than leg pain.  Therefore, it is imperative the patient try every form of non-fusion care before going down the one-way street of fusion, for there is no turning back!

Lumbar Fusion: General Information

Lumbar fusion is a very invasive (destructive) type of spine surgery that is performed in over 400,000 Americans each year because of intolerable low back pain, [4,39] and its frequency of use is skyrocketing. In a 2012 publication, Rajaee et al. reported a 137% increase in the utilization of lumbar fusion between 1998-2008, which was higher then either hip or knee replacement surgery. [39]

lumbar interbody fusionIn addition to this significant rise in utilization, the cost of a single fusion surgery has reached an astonishing $81,960, which represents a 3.3 fold increase since 1998, [39] and the yearly price tag for all fusions performed in the US, as last calculated in 2008, was a staggering $33.9 billion. [39]

Figure left represents a modern interbody fusion in which the pain-generating disc has been replaced by a cage (interbody spacer) that is surrounded by bone chips (or other fusion material), which are usually taken from the patient's own hip. Bone chips (bone graft material) are also packed between the especially-prepared transverse processes and/or between the facet/lamina region of the two vertebra. Posterior instrumentation, i.e., rods and screws, are also inserted and cinched down in order to place the motion segment in the proper sagittal alignment (slight extension) and, like a cast, will hold the motion segment very still while the bone chips to "ossify" or "harden."

What Does the Research Say? Confusion?

Notwithstanding its financial strain on the US economy, the efficacy (safety and effectiveness) of lumbar fusion remains equivocal (debatable) as demonstrated by the recent publication of two meta-analyses (a special type of study that puts forth the highest level {level I} of scientific evidence) that have failed to demonstrate fusions superiority to simple (and much less costly) nonoperative care, such as physiotherapy and exercise. [40,41]

On the other hand, there is still the Volvo Award-Winning study of Fritzell et al. [48] which was a multi-center randomized-control trial (which is also level I evidence) that demonstrated lumbar fusion significantly outperformed nonoperative care with regard to pain decrease, functional improvement, satisfaction, and return to work. [48] Then there was the other famous multi-center randomized-control trial (the SPORT study) by Weinstein et al. [53] that concluded spondylolisthesis and stenosis patients achieve superior fusion outcomes (how good the patient thinks he or she did after the fusion) when compared to nonoperative care and held that improvement until the end of the study, which was four years. [53]

So what should a person believe? The meta-analysis or very well-done randomized control trial? First of all let me say that these level I meta-analyses always seem to come up negative with regard to any type of treatment perhaps because it's just not right to compare apples with oranges. A meta-analysis puts forth its opinions by pooling the data from many different papers on the subject, many of which used subtle differences in surgical technique, data collection methodology, and different outcome questionnaires. Therefore, I just don't believe that they are as powerful as a well designed multicenter randomized-controlled trial and should be taken with a grain of salt. I'm not the only one to feel this way. Check out the quote from Penta et al. [54] with regard to what type of study should be used to verify efficacy of the procedure:

"The only accurate way of assessing the role of lumbar fusion in the treatment of low back pain is by prospective, randomized, controlled, long-term studies comparing spinal fusion with nonoperative treatment."

There is no question that spinal fusion has its rightful place amongst the arsenal of weapons that we have to treat chronic intractable spine pain; however, its must be used judiciously and performed in just the right patient by just the right surgeon. *In fact, choosing a spine surgeon to do the fusion is most likely more important than the actual technique that he or she uses. I can't stress this point enough; you have got to do your homework when selecting a surgeon.

Although lumbar fusion should never be used for a run-of-the-mill paracentral disc herniation, it has been found efficacious (safe & effective) for the treatment of scoliosis, spondylolysis, spondylolisthesis, stenosis, internal disc disruption, isolated disc reabsorption, facet syndrome, vertebral endplate syndrome, recurrent disc herniation, and giant disc herniation, as well as for fracture, tumor and infection of the spine.

Fusion History

The first fusion was performed in 1911 by Albee et al. [31] who used bone from the tibia (leg bone) in order to perform a crude posterolateral fusion (PLF) for a patient suffering painful tuberculosis of the spine. [31] The technique then underwent several important modifications (especially by the addition of posterior instrumentation) over the years until the modern version of PLF came to being as reported by Wiltse in 1975. [32] (We shall talk more about the techniques farther below.)

The first interbody fusion was described by Cloward in the early 50s [44,45] and was used as an alternative to simple discectomy, which was having miserable results at the time. Instead of a metal alloy cage, a fashioned bony plug was inserted for a posterior approach and acted as the interbody spacer; posterior instrumentation was not used. This technique was named posterior lumbar interbody fusion (PLIF) and is still used today; however, it is associated with higher post-fusion morbidity (it tends to hurt patients more) and has really fallen out of favor because of the magnitude of bony destruction necessitated and the long nerve root retraction times.

Posterior lumbar interbody fusion soon evolved into a variety of other interbody fusion techniques ("interbody" means that the center of the disc was removed and a sturdy replacement {usually a cage} was installed) that include anterior lumbar interbody fusion (ALIF), transforaminal lumbar interbody fusion (TLIF) and 360° fusion, all of which will be discussed farther on down the page. There are other even more recent fusion techniques which are still considered experimental and will not be discussed here.

All of these fusion techniques can be performed via "minimally invasive surgery" (MIS), which again will not be discussed here, for they are still considered experimental in my book.

Fusion Recovery

Recovering from fusion (especially interbody fusion) is typically not a piece of cake, for during the procedure a significant amount of tissue is destroyed and injured, which takes time to heal. Plan on being out of work for at least 2-3 months and even longer if your job is arduous. Another important fusion fact is that you will (or at least should) have permanent limitations with regard to heavy lifting; repeated bending, twisting, and stooping at the waist; and participating in contact sports or similarly physical activity. Without these limitations, you may very well end up needing revision surgery in the not so distant future.

Fusion Complications

Unfortunately, it is not uncommon for complications to occur during and after the fusion procedure. Such complications include dural tear, vertebra fracture, nerve root injury, bone/disc infection, seroma/hematoma formation, wound infection/dehiscence, blood clot/pulmonary embolism, pseudoarthrosis (failure of the motion segment to fuse together), hardware irritation/failure, cage displacement and adjacent-segment disease (ASD), which may or may not require revision (second) surgery.

If recombinant human bone morphogenetic protein-2 (rH-BMP-2) was used during the procedure, then the additional complications of vertebral body destruction (osteolysis), excessive bone growth into the spinal canal (heterotopic bone growth), and even the possible development of cancer; [43] however, the jury (no pun intended) is still out on this possible complication as other studies have shown no relationship between rH-BMP-2 and cancer. [52]

Although rates of revision surgery after fusion can be surprisingly high, [14] for patients who are an ideal candidate and have found a spine surgeon with an outstanding record of fusion success, the clinical outcomes (how good the patient thinks the surgery did) and patient-satisfaction can be quite high.

Lumbar Fusion: How Does it Fixed the Pain?

A motion segment (i.e., a vertebra-disc-vertebra complex) typically generates chronic back pain when inflamed nociceptive nerve fiber (pain-carrying nerves) within the disc, facets, endplates, and/or fractured pars interarticulari becomes mechanically irritated from the natural movement of the motion segment which results from the activities of daily living (i.e., getting out of bed, putting on clothing, preparing meals, going shopping etc.). In other words, when the motion segment moves, it hurts.

Fusion RegionTherefore, as the theory goes, in order to stop the pain, you must permanently stop the movement of the motion segment, which is accomplished by a spine surgery called fusion.

In the simplest of terms, this surgery "fuses" (welds, glues or ossifies) the two vertebra of the motion segment into one solid unit, thereby eliminating the pain-generating movement.

Figure left is a sagittal view (from the side) of a typical lumbar motion segment. In order to stop all movement and eliminate pain, the motion segment is fused in the posterior column (red circle) by packing bone chips (often taken from the patient's own hip) into the spaces between the transverse processes (TP) and prepared (decorticated) facet/lamina region. With the passage of time, these bone chips will grow into one mass and "glue" the posterior column of the motion segment firmly together. Often times, in addition to the posterior column fusion, the nucleus and part of the annulus will be removed and replaced by a spacer (cage) which is surrounded by bone chips. Again, with the passage of time the bone chips grow into one mass and unite the two vertebral bodies. (See image left "fused.")

If only the posterior column is fused, then the procedure is called a posterolateral fusion. (PLF) If the anterior column is fused as well, then the procedure is called an interbody fusion.

The goal of every fusion surgery is to achieve a solid ossification (solid fusion or arthrodesis) between the two vertebra of the motion segment, for recent medical research has demonstrated that patients who are successfully fused, have significantly better clinical outcomes. [35]

Lumbar Fusion: The High Rate of Failure

PLF fusionUnfortunately not only is fusion the most invasive (destructive) type of spine surgery, it also has one of the highest rates of failure, which has been calculated at 13% in a very large study of 1,680 patients with five years of follow-up. [14]

Figure 1 is a cartoon depiction of the posterolateral fusion (PLF) procedure, which has been completed only on the left. In reality it's done on both sides and used to eliminate all pain-producing motion in the posterior column of the motion segment. Although it might be an effective treatment intervention for conditions of instability (i.e. spondylolytic spondylolisthesis and fracture), PLF does not eliminate all motion in the anterior column (which is where the disc is) and therefore is a poor choice for treating discogenic pain.

In other words, you could say that at least 1 out of every 10 patients will be forced to go through a second spine surgery within five years from the date of the first spine surgery because of recurrent pain. [14]

Anecdotally, the rate of failed fusion (as defined by poor patient satisfaction after the fusion) has been placed at 33%! *Don't stop reading, however, for fusion certainly can be a real lifesaver if you are the right candidate, and I know of many fusion success stories.

Why Does fusion fail? The Domino Effect

One of the reasons for the high rate of fusion revision surgery is because of a well-known phenomenon called the "domino affect." The domino effect, which is more properly called adjacent segment pathology (ASP) or adjacent segment degeneration (ASD), is said to have occurred if either the motion segment above or below the original site of fusion develops a premature and painful degenerative process, which in turn may necessitate revision surgery. Interestingly, it's almost always (90% of the time in one study) the motion segment above the level of fusion that becomes painful and necessitates revision surgery after fusion. [17,18]

What causes ASP? When one of the five motion segments of the lumbar spine is fused (*especially if the surgeon fails to fuse the motion segment with sufficient lordosis), there is a disruption of the axial load and motion sharing that naturally occurs equally between all segments. However, when one motion segment is fused, the segment above (and to a lesser extent below) has to do double-duty with regard to handling trunk movement and axial load, which in turn may cause rapid degenerative disease and lead to a new source of pain. [18] Although, a failure of the adjacent disc (i.e., it develops painful annular tears and/or herniations) is usually the cause for second surgery, the development of a painful facet syndrome or stenosis may also occur.

Fusion Techniques: PLF, PLIF, TLIF, ALIF & 360° Fusion

PLF | PLIF | TLIF | ALIF | 360°Fusion

What's the quickest way to start a brawl in a room full of spinal surgeons? Ask them "what is the best fusion technique for the treatment of chronic discogenic low back pain?" Many spine surgeons are strongly opinionated when it comes to their craft and rarely can agree (sometimes notwithstanding quality research) which technique is best for treating a specific diagnosis—their way is always the best way.

So which one is the best? That really depends on the patient's unique situation, and I would be happy to discuss this with you privately through one of my Coaching Sessions.

Let's talk about the most common fusion techniques.

Posterolateral Fusion (PLF)

 posterolateral fusionOf all the fusion techniques, PLF (the first spinal fusion technique ever created) is the least invasive, for it does not require entering the epidural space and therefore eliminates the possibility of lumbar nerve root and/or thecal sac injury. *Once nerve roots are damaged via during interbody fusion, they often go on to cause life-long chronic lower extremity pain.

Posterolateral fusion is the grandfather of all fusion techniques and was developed just over 100 years ago by Albee et al. [31] Since then, PLF has come a long way and is still used by surgeons to correct posterior column problems, such as spondylolysis and spondylolisthesis. It is also used to correct structural deformities such as scoliosis.

Figure 6 is a from-behind view (PA view) of a lumbar spine that is opened up (the skin, fascia, and muscles are dissected and pulled away from the lumbar spine) for the PLF procedure. Note that bone chips have been packed between the decorticated transverse processes, facets, and lamina on the right at L3/4 and L4/5 (green dot). The surgeon, who has just finished decorticating (roughing up) the right transverse processes (orange dot), is now about to pack bone chips on the left side to complete the surgery. Posterior instrumentation was not used this time.

One of the most common conditions treated by PLF is spondylolisthesis. I won't re-described the condition (read all about it here) but you should know that if you add posterior instrumentation and decompression to the PLF procedure, your chances for a superior clinical outcome after the fusion significantly increase. [38]

Furthermore, you probably do not need that anterior lumbar interbody fusion (ALIF) or posterior lumbar interbody fusion (PLIF) for the treatment of symptomatic spondylolisthesis, for research has demonstrated that instrumented PLF with decompression is just as effective as ALIF [36,37] and more effective than PLIF. [46]

On the other hand, the treatment of discogenic pain (from isolated disc reabsorption, internal disc disruption, or recurrent herniation) is not well accomplished by PLF, for discogenic pain is a problem with the anterior column and therefore needs one of the interbody fusion techniques to create the needed anterior and posterior column fusion. Posterolateral fusion will not fuse the anterior column, and pain-generating micro-motion will continue to occur there, notwithstanding the fusion. [33]

Posterior Lumbar Interbody Fusion (PLIF)

In the mid-1940s, Dr. Ralph Cloward [44,45] developed a novel (new) type of fusion for the treatment of disc herniation. The impetus for this innovative surgical technique was the poor results that he was achieving with the discectomy procedure of the time—70% of these patients had poor outcomes. Therefore, he stopped using discectomy and over an eight-year period performed 321 consecutive fusions using a technique that he called posterior lumbar interbody fusion (PLIF). The results of this history-making experiment, which were reported in 1952, demonstrated that 85% of the patients achieved a very satisfactory outcome. [45]

*Anecdotally, the most likely explanation for Cloward's poor discectomy results was because back in those days they didn't understand that certain conditions of the disc (central disc herniation, small contain disc herniation, disc bulge, recurrent disc herniation, isolated disc reabsorption, and internal disc disruption) respond very poorly to discectomy and such as surgery shouldn't have been performed in the first place.

PLIFFigure left demonstrates how Cloward's PLIF technique was performed, which is quite similar to how it is performed today: first, as noted in figure left, a wide laminotomy is carried out (red arrows) which, destructively, creates a large window at the disc level. In other words, a hole is cut in the posterior portion of the lumbar spine in order to again access to the disc space.

Next the traversing nerve root and the thecal sac are retracted out of the way (black arrows) in order to expose the pain-generating disc. Then the entire half of the disc is removed, except for the anterior and the lateral annulus fibrosus, which leaves a hollow space (large pink star).

Next, while retraction of the neural structures remains in effect, bone plugs (we use metal alloy cages or spacers in this day and age) are jammed into the disc space which will eventually ossify and unite (fuse) the two vertebral bodies of the motion segment into one unit (not shown).

Next, the same procedure will be carried out on the opposite side: the side opposite traversing nerve root and thecal sac will be tractioned out of the way, the disc tissue will be removed, and bony plugs will be jammed in to the disc space.

PLIFFinally, bone chips (bone graft material), which have the capability to ossify together like glue, will be used to fill in the wide laminotomy in order to fuse (weld together) the posterior column of the motion segment into one unit. [44,45] (Figure left)

In addition to Cloward's procedure, in this day and age, posterior instrumentation (pedicle screws and rods) is employed on each side in order to stabilize the motion segment while ossification occurs and to asssure that the vertebrae are in sagittal alignmennt (slight extension). This instrumentation could later be removed.

Although PLIF was a very effective intervention in its day, it has really fallen out of favor and given way to some of the less invasive interbody fusion techniques, such as TLIF and ALIF, which do not require such prolonged retraction of the neural structures (ALIF does not require any retraction, for it does not even enter the epidural space). Furthermore, because of the potential for spinal cord damage, PLIF is limited to the L3-S1 levels. In other words, if you have a L1 or L2 problem that needs fusion, PLIF cannot be performed. [51]

Such traction techniques have been associated with permanent nerve root damage and resultant chronic radicular pain. In fact in one 2002 study, 13.6% of the patients treated with one PLIF technique ended up suffering permanent iatrogenic (from the procedure itself) nerve root damage with resultant chronic radicular pain at follow-up! [47]

Let's move on to the more popular techniques.

Transforaminal Lumbar Interbody Fusion (TLIF)

One of the more popular interbody fusion techniques is called transforaminal lumbar interbody fusion (TLIF), which was first described by Harms and Jeszenszky in 1998. [7]

Unlike PLIF, which destroys much of the posterior arch (both facets, laminae and spinous process) and requires prolonged neural structure retraction on both sides, TLIF is much less destructive and requires only minimal (if any) unilateral (only one side) retraction. [8,9] Undoubtedly because of the minimized nerve root retraction, medical research has demonstrated that the TLIF technique results in less iatrogenic nerve root damage (i.e., postoperative radiculitis) as compared to PLIF. [49]

In a nutshell, here's how the technique works: after the skin, fascia, and muscle posterior to the motion segment is dissected and retracted away (just like in the PLF and PLIF procedures), the pain-generating disc is approached posterolaterally in order to enter the epidural space through the facet joint (which is usually completely removed {red, figure below).

TLIFThis approach puts the surgeon into the posterolateral region of the epidural space which is considered a safe-zone called Kambin's triangle. The reason it is called the safe-zone, is because it is right in between the exiting and traversing nerve roots.

Figure left is a posterior to anterior view of the L4/5 motion segment that represents a typical transforaminal lumbar interbody fusion with PLF augmentation and instrumentation. Note how the left facet (area between red) has been removed and a cage (green) has been inserted through the posterolateral disc via the annulotomy, into the disc space. Note the posterior instrumentation (pedicle screws and rods) as well as the strips of bone which represents the PLF.

Therefore, very little retraction of either of the nerve roots will be necessary; although, they will have to be at least protected by the retractor, so some nerve root contact is inevitable, but not nearly as much as with TLIF.

Next, using special tools the surgeon will create a box-shaped hole in the posterolateral annulus fibrosus of the disc, through which all the work will be done. Next, as much of the nucleus pulposus as possible will be removed and then the endplates will be will be scraped away with just enough force to create a tiny amount of bleeding of the subchondral bone. It is important that the surgeon doesn't scrape away too much bone, for this could weaken the subchondral bone and allow the cage to collapse or sink into the vertebrae postoperatively, which is a complication called subsidence.

After the disc space is prepared, an interbody graft (cage) (green, figure above), which is typically made of polyetheretherketone (PEEK) will be inserted and then bone chips will be packed all around it in order to fuse the vertebral bodies of the motion segment together.

Next, very carefully (some surgeons use Stealth technology to guide them) pedicle screws will be inserted above and below in both vertebra of the motion segment and rods will be attached to those. The rods can then be cinched down in order to establish the proper sagittal alignment (extension) of the motion segment.

The pitfalls of this technique are (1) there is a steep learning curve and (2) the workspace for the surgeon is limited compared to traditional PLIF, which removes both lamina and the spinous process.

Transforaminal Lumbar Interbody Fusion: the research

Unfortunately, and perhaps surprisingly, to date there continues to be not a single randomized control trial (level I evidence) that compares TLIF to either PLIF or ALIF. (see my Medline search)

Hackenberg's 2005 prospective investigation on the efficacy of TLIF, [51] is the one commonly reported, so let's review that quickly. Hackenberg prospectively treated 54 patients with instrumented TLIF, without rH-BMP-2 augmentation, with the goal of studying their long-term outcomes. 93% of the patients were available for a three year assessment which revealed a significant decrease in pain, increase inability to function, and an 89% rate of solid fusion. There was, however, an 8% serious complication rate that included one case of infection (all the instrumentation had to be removed in the fusion had to be repeated from the entry approach); one case of unfixable radiculopathy (the surgery created a new sciatica); and one contralateral herniation, which was thought to have occurred because not enough of the nuclear material was removed during the surgery. [51]

All in all, TLIF, which is being performed with minimally invasive techniques these days {we can talk about that during a coaching session if you want, but I won't discuss it here}, is probably my favorite fusion technique as it avoids excessive manipulation of the nerve roots and is more minimally invasive than ALIF or PLIF.

Anterior Lumbar Interbody Fusion (ALIF)

Anterior lumbar interbody fusion, which is sometimes called a stand alone ALIF, is an interbody fusion procedure that accomplishes fusion between the vertebral bodies of the motion segment by approaching them from the front (i.e., through the belly). Although such an approach spares contact with the delicate posterior neural structures (i.e., the cauda equina, nerve roots, spinal nerve and dorsal root ganglia) and eliminates any posterior muscle damage that is associated with the posterior fusion procedures, ALIF is associated with male sterility via a condition called retrograde ejaculation.

A modern version of the ALIF procedure was first reported by Lane et al., 1948 [55] where he described the surgical technique in detail and reported the clinical outcomes of 35 patients who had been treated by this ALIF procedure—94% of them had experienced a significant reduction in pain; however, only 17% of them were pain-free.

ALIF Limitations

Because the ALIF procedure is unable to reach most of the epidural space, it is not effective for the treatment of spondylolisthesis, spondylolysis, central stenosis, or even lateral stenosis. It is better designed for the treatment of disc-related problems (isolated disc reabsorption, internal disc disruption, or reoccurrence disc herniation).

Anterior lumbar interbody fusion is also an option for treating patients who had suffered a failed posterior fusion procedure. In these patients, you don't want to go through the epidural space again in order to correct a pseudoarthrosis (failure to fuse). Therefore, it's best to come from the anterior in order to fixed the problem.

Another big limitation stems from the fact that ALIF can only be used problems at the L4 and L5 motion segment. This is because the inferior vena cava and aorta block the anterior disc space above the L4 level.

ALIF Complications: Retrograde Ejaculation

Besided complications of pseudoarthrosis, vertebral body fracture, and all the other complications mentioned for the other fusion procedures, ALIF is the only fusion procedure that could make the male patient infertile after the procedure, via a condition called retrograde ejaculation.

The hypogastric plexus, which contains the nerves to the bladder and urethra, is in very close proximity to the anterior portion of the L4 and L5 discs. Although we are still not sure of the mechanism, between 0.4% and 6% of men will lose the ability to ejaculate sperm from the penis (the sperm harmlessly goes into the bladder instead) after the ALIF procedure, and become completely infertile. [56-58]

Of the two approaches that can be used to complete ALIF, is the transperitoneal approach that has a higher chance of causing male sterility. More specifically, medical research has demonstrated that there is a 10 times greater chance of suffering retrograde ejaculation with the transperitoneal approach, when compared to the retroperitoneal approach. [58]

Does ALIF Work? The Research

Quality randomized-control trials comparing ALIF to either TLIF or PLIF did not exist at the time of this writing (May, 2014). Therefore, we must use lesser quality evidence to establish efficacy. In other words, we have to use a retrospective study to see if this type of fusion actually works and is safe.

In 1997, Penta and Fraser [54] reported the results of their retrospective study which followed a group of 125 patients who were treated with ALIF, mainly for the diagnosis of discogenic pain. The beauty of this rare study was that these patients were followed for 10 years and that 82% of them were still available to answer questions at that time point. Although 78% of the patients reported either complete or good relief from their chronic back and/or leg pain, only 34% had a good or excellent return of function. In other words, the pain was no longer a problem for most of them; however, they were unable to function at a very high level with regard to activities such as moderate to heavy work, sports, or other similar activities. [54] Do these findings remind you of something you just read? These findings were actually quite similar to the very first outcome study ever performed on ALIF, which was done almost 70 years ago! [55]

360° Fusion

To Make up for some of the inherent weakness of stand-alone ALIF, surgeons will commonly add the PLF fusion procedure to the ALIF procedure, which results in a technique called 360° Fusion. [36,37]

Now, the procedure can address common conditions such as spondylolisthesis and stenosis; however, 360° fusion requires much more time on the operating table or requires coming back to the operating room a few days after the ALIF is completed.

Does 360° Fusion Work?

Although I know spine surgeons who swear by the procedure, the research doesn't support it very well. For example, in 2002 Christensen et al. reported the results of their randomized control trial that compared instrumented PLF against 360° fusion for the treatment of degenerative spondylolisthesis. At the two-year follow-up, there is no difference between the patient outcomes as both groups of patients improved statistically the same—78% patient satisfaction was reported in both groups. [36] The same groups of patients were followed an additional three years which revealed similar results: there was no difference in outcomes between the two groups. However, The 360° Fusion patients did have a higher rate of successful interbody fusion and needed fewer reoperations. [37]

Artificial Disc Replacement

This is a very big topic and at this point, I am just not going to cover it. I would be more than happy to discuss the pros and cons of the various types of lumbar arthroplasty via one of my Coaching Sessions.

Fusion Alternatives!

Medication | Decompression Surgery | Experimental Treatments | Epidural Steroid Injections | Sacroiliac Injections |

Since fusion doesn't have the greatest track record, and its failure has the potential to result in horrible life-long pain, please consider trying all other types of non-fusion care first, which include bedrest; permanent activity modifications; medication; bracing; physical therapy & exercise; low-force chiropractic care; acupuncture; injective procedures; and (if stenosis or recurrent herniation are the problems) a decompressive spine surgery, such as laminotomy, laminectomy and/or foraminotomy.

Although I won't get into all the common types of conservative care, I will talk about medication, decompressive surgery, epidural steroid injections, and experimental treatments him.

Medication

oxycodoneHands down, the most common type of treatment for low back pain is the use of medication, which is prescribed for 80% of patients entering their primary care physician's office on the first visit. [23]

Over-the-counter medications, such as acetaminophen (Tylenol) and ibuprofen (Advil) are also effective for certain types of pain.

The most common of prescription medications him him and are nonsteroidal anti-inflammatories, (NSAIDs) muscle relaxers, and opioids. [23-25] However, benzodiazepine, corticosteroids, antidepressants, and antiepileptic medication are also used, only less frequently. [26]

Medication: the Research

Surprisingly, there is not much quality research published on the long-term efficacy (> 6 months) use of any medication for the treatment of chronic back pain, for the Lions' share of data comes from studies with only four months or less of treatment.

One very high quality meta-analysis (level I evidence) recently looked at the efficacy of opioids (Vicodin, Percocet, or MS Contin) for the treatment of chronic low back pain. [21] Specifically, after pooling the data from 5,540 patient who had participated in only quality randomized controlled trials with placebo, Chaparro et al. reported that in the short term (four months) opioids were more effective than a placebo (a fake sugar pill) at reducing chronic back pain and increasing patient function; furthermore, there were no serious adverse effects reported with the opioids. [21] This team of researchers also compared NSAIDs to opioids in failed to present strong or even moderate evidence that NSAIDs were as effective as opioids. In other words, opioids are still better for the treatment of chronic low back pain. [21]

Chou et al. [22] published the results of their systematic review which pooled data from randomized control trials that investigated different types of medication for the treatment of chronic back pain. They concluded that there was "good" evidence supporting a four-month trial of NSAIDs, muscle relaxers, or tricyclic antidepressants for the treatment of chronic back pain. [22] On the other hand, the also discovered that corticosteroids were ineffective for the treatment of chronic low back pain with or without sciatica. [22]

Because every patient has unique biochemistry, what works for one patient may not work for another; therefore, I believe that all of the aforementioned medications must be tried in attempts to prevent fusion. Such experimentation, however, must be carried out under the direct supervision of your primary care physician and or chronic pain specialist.

Anecdotally, chronic neuropathic pain in the lower extremity seems to respond favorably to either Neurontin or, it's a more modern form, Lyrica. Unfortunately, both medications (Neurontin >Lyrica) have the unwanted side effect of "brain fog" which takes some getting used to; I could never get used to it, and had to discontinue both medications. Him him

Decompressive Surgery: Still More Conservative Than Fusion

For patients with very large or recurrent disc herniation, as well as stenosis, a choice between decompressive surgery (i.e., laminectomy, laminotomy, foraminotomy) and interbody fusion may be offered.

If this happens, which one do you try? And, if the decompression is tried, what happens if it fails? I mean, will it decrease the chances of having a successful subsequent fusion? Although the answer to the first question will depend on many factors, so I cannot answer it here. [Remember I do offer a Coaching Service where I can help you make this decision] The answer to the last question is probably not. How do I know? I actually designed and published a medical investigation geared at answering this very question. [20]

Specifically, in 2014, Gillard et al. [Dr. Gillard, that's me] [20] published the results of a rare study that compared the fusion outcomes of two groups: a group that underwent decompression prior to fusion, and a group that did not. At an average follow-up of 40.4 months, both groups demonstrated high patient satisfaction; however, there was no statistical difference between groups with regard to clinical outcomes at the last follow-up. [20] In other words, at least in this small study, trying a decompressive surgery prior to fusion does not seem to negatively affect medium term clinical outcomes.

The Experimental Treatments

There are other "experimental" procedures out there, many of which I have discussed on my Spine Research Page, which have been touted as fusion alternatives. These include, SED, discTRODE, Nucleoplasty, PIRFT, RF-Denervation, Spinal Cord Stimulation, IDET, Chemonucleolysis, Prolotherapy, Intradiscal PRP Injection, and Intradiscal Steroid Injection. Unfortunately, the patent holders of these procedures still have not put them through vigorous randomized controlled trials; therefore, I just don't believe that they should be considered at this time. [19] I have written about many of these procedures on my research page, so if you want to know more, that's the place to go.

Intradiscal Biacuplasty

Intradiscal biacuplasty, however, is one fusion alternative that may have demonstrated its efficacy (safe and effective treatment) and may be worth considering. I have already discussed this technique in depth on the disc herniation page, so if you're interested, please click here to learn more.

Epidural Steroid Injections

Although epidural steroid injections are typically thought of as a treatment for lower extremity pain, they may also help, at least temporarily, with discogenic low back pain and are certainly worth a try. Again, I have already discussed this technique in depth on the disc herniation page, so please click here if you want to learn more.

Sacroiliac Joint Injections

Anecdotally, it is well known discogenic pain syndrome (i.e., pain coming from an annular tear, endplate pain syndrome, or disc herniation) does refer pain into the sacroiliac (SI) joints in some patients.

Therefore, before undergoing fusion for chronic discogenic pain, SI joint blocks should be performed in order to rule the SI joint out as a pain generator. You certainly would not want to have lumbar interbody fusion if the pain generator was really the SI joint! If this were the case, that fusion would have been a complete waste of time can cause serious harm to your lumbar spine.

The SI joints also may become a new source of low back pain after a successful lumbar fusion. [29] This phenomenon occurs because, as mentioned before, fusion screws up the biomechanics of the lumbar spine and not only overloads the segment above the fusion, but also overloads both sacroiliac joints, which can lead to premature degeneration and pain. In fact, in one 2008 study, Ha et al. [29] demonstrated that 75% of fusion patients had CT evidence of significant SI degeneration five years after their fusion, as compared to 38% of asymptomatic people in a control group who also had the CT performed at five years. [29]

A dysfunctional and painful SI joint, which may occur in up to 18% of people with chronic low back pain, [27] is very hard, if not impossible, to clinically diagnose. [28] Computed tomographic findings of joint destruction continues to be the gold standard. [30]

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