The Top Seven Chiropractic Randomized Controlled Trials:

1) Aure OF, Nilsen JH, Vasseljen O. - Spine 2003 28(6):525-31; discussion 531-2

2) Triano JJ, McGregor M, Hondras MA, Brennan PC. - Spine. 1995 Apr 15;20(8):948-55.

3) Giles LGF, Muller R. - Spine 2003;28(14):1490-1503

4) Muller R, Giles LG. - J Manipulative Physiol Ther. 2005 Jan;28(1):3-11.

5) Hoiriis KT, et al. - J Manipulative Physiol Ther. 2004;27(6):388-98.

6) Koes BW, Bouter LM. - BMJ. 1992 Mar 7;304(6827):601-5 .

7) Niemisto L, et al. - Spine. 2003 Oct 1;28(19):2185-91.

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1) Aure OF, Nilsen JH, Vasseljen O. ‘Manual therapy and exercise therapy in patients with chronic low back pain: a randomized, controlled trial with 1-year follow-up.” Spine 2003 28(6):525-31; discussion 531-2 Forty-nine patients were randomized into either an exercise group or a spinal manipulation group: “ CONCLUSIONS: …manual therapy (aka: manipulation or mobilization) showed significantly greater improvement than exercise therapy in patients with chronic low back pain. The effects were reflected on all outcome measures, both on short and long-term follow-up (1 year).” “Immediately after the 2-month treatment period, 67% in the manual therapy and 27% in the exercise therapy group had returned to work.”

2) Triano JJ, McGregor M, Hondras MA, Brennan PC. ‘Manipulative therapy versus education programs in chronic low back pain.’ Spine. 1995 Apr 15;20(8):948-55. Conclusion: “ there appears to be clinical value to treatment according to a defined plan using manipulation even in low back pain exceeding 7 weeks' duration. ” “Greater improvement was noted in pain and activity tolerance in the manipulation group. Immediate benefit from pain relief continued to accrue after manipulation.”

3) Giles LGF, Muller R. ‘A Randomized Clinical Trial Comparing Medication Acupuncture and Spinal Manipulation.’ Spine 2003;28(14):1490-1503 “ The results of this efficacy study said just that spinal manipulation, if not contraindicated, may be superior to needle acupuncture or medication for the successful treatment of patients with chronic spine pain syndrome…."

4) Muller R, Giles LG. ‘Long-term follow-up of a randomized clinical trial assessing the efficacy of medication, acupuncture, and spinal manipulation for chronic mechanical spinal pain syndromes.’ J Manipulative Physiol Ther. 2005 Jan;28(1):3-11. “ CONCLUSIONS: In patients with chronic spinal pain syndromes, spinal manipulation, if not contraindicated, may be the only treatment modality of the assessed regimens that provides broad and significant long-term benefit.”

5) Hoiriis KT, et al. ‘A Randomized (Placebo-Controlled) clinical trial comparing chiropractic adjustments to muscle relaxants for subacute low back pain.’ J Manipulative Physiol Ther. 2004;27(6):388-98. “ Chiropractic was more beneficial than placebo in reducing pain and more beneficial than either placebo or muscle relaxants in reducing Global Impression of Severity Scale.”

6) Koes BW, Bouter LM ‘Randomised clinical trial (with placebo) of manipulative therapy and physiotherapy for persistent back and neck complaints: results of one year follow up.’ BMJ. 1992 Mar 7;304(6827):601-5. “ CONCLUSIONS--Manipulative therapy and physiotherapy are better than general practitioner (medication) and placebo treatment. Furthermore, manipulative therapy is slightly better than physiotherapy after 12 months.”

7) Niemisto L, et al. “A randomized trial of combined manipulation, stabilizing exercises, and physician consultation compared to physician consultation alone for chronic low back pain.” Spine. 2003 Oct 1;28(19):2185-91. “ The manipulative treatment with stabilizing exercises was more effective in reducing pain intensity and disability than the physician consultation alone (in a group of 204 chronic low back pain patients).” “ The present study showed that short, specific treatment programs with proper patient information may alter the course of chronic low back pain.”

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